• Hot Saucerman@lemmy.ml
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    1 year ago

    I think allergy suffers already have known this for years… The stuff that works is locked up because it can be used to make meth…

    • dublet@lemmy.world
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      1 year ago

      Yes, it’s pseudoephedrine that you want. Somewhat ironic that Sudafed got its brandname from it, but you can’t easily get the original version anymore.

      Edited: corrected for availibility of the Sudafed - thanks Blue and Cubby.

    • some_guy@lemmy.sdf.org
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      1 year ago

      A frustrating outcome. I used to buy 14 day packs of allergy meds and sometimes didn’t qualify to buy more two or even four days after I ran out. I don’t know what aspect of their restrictions allow this to happen, but it’s bullshit. Also, good luck if you’re going overseas for a month and need a full supply. I believe a doc can prescribe a larger supply, but I shouldn’t have to pay more money and time for a doc appointment to get that.

      • BOMBS@lemmy.world
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        1 year ago

        One thing I’ve realized about US healthcare is that it would rather restrict meds from those that need them than to give access to those that would abuse it.

    • x4740N@lemmy.world
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      1 year ago

      Any backyard chemsit can make meth if they are skilled enough

      Nile Red likely has the capability of doing that

    • aesthelete@lemmy.world
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      1 year ago

      Probably in the minority here but I didn’t know that Benadryl straight up doesn’t work as a decongestant. It knocks me the fuck out though, so I wonder if it’s effective at making you drowsy as shit and not much else.

      • prole@sh.itjust.works
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        1 year ago

        The person you replied to was talking about pseudoephedrine, which is marketed as a decongestant. And boy does it get the job done.

        Benedryl (diphenhydramine), on the other hand, is an anti-histimine and it absolutely works for allergic reactions. That said, it’s also marketed as a sleep aid (take a look at the active chemical in things like “ZZZQuil” or drug store brand “sleep aid,” and compare it to the one in Benedryl. Same chemical), and believe me, it works very well for that.

        I dunno if I would use it as a decongestant.

      • Case@unilem.org
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        1 year ago

        Benadryl is one of the stronger sedatives, prescription or not, if I recall correctly (CPhT, lapsed)

  • starman2112@sh.itjust.works
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    1 year ago

    Representatives for the Consumer Healthcare Products Association, a group that represents OTC drug manufacturers, did not offer any new evidence to counter the FDA’s claims that the drug is ineffective during their presentation Monday.

    The group instead said that if oral phenylephrine were not available over the counter, it would be a significant burden to consumers.

    But it doesn’t work! Consumers are literally using something that’s no better than the naturopathic bullshit found in the next aisle over!

    MAN I hate corporate lobbyists. Outright lying to try and save face.

    • dantheclamman@lemmy.worldOP
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      1 year ago

      “It is difficult to get a man to understand something, when his salary depends on his not understanding it.” -Upton Sinclair

      • Astroturfed@lemmy.world
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        1 year ago

        Yes, I NEED this shit like 2-3 months of the year due to a severe winter cedar allergy. I can barely function without a strong decongestant and having to show my ID and jump through hoops at the pharmacy to get it instead of just grabbing some off a shelf is so frustrating.

    • Bgugi@lemmy.world
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      1 year ago

      Lol, thinking that the naturopathic shit isnt sitting on the same shelves with almost identical packaging to real medicine.

    • SeaJ@lemm.ee
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      1 year ago

      Burden to consumers = burden to our profits for selling useless bullshit

  • roguetrick@kbin.social
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    1 year ago

    No shit. The fun part is it DOES have side effects. So it doesn’t do what it’s proclaimed to do, but is a drug. It should be pulled off the shelves.

  • sssm@lemmy.world
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    1 year ago

    Super interestingly, in clinical trials it is less effective than the placebo.

    • misterundercoat@lemmy.world
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      1 year ago

      Yeah man you gotta go to the counter and sign a log book to get the good stuff, thanks methheads. Don’t fall for the PE version on the shelves, that’s a noob trap.

    • Astroturfed@lemmy.world
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      1 year ago

      Yes. I have a few months a year where I have to get some type of decongestant and the most cost effective is generic Pseudoephedrine. It works. My mother bought me phenylephrine a few times when I was younger and it just didn’t do anything. Not surprised about this article one bit.

  • TheAmishMan@lemmy.world
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    1 year ago

    I graduated pharmacy school 8 years ago. This was a thing that was taught in school. This is why you should talk to your pharmacist. Guaifenisin is another ‘garbage drug’ that does virtually nothing; just drink more water

    • kmkz_ninja@lemmy.world
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      1 year ago

      Guaifenisin seems to clear my chest congestion up pretty quickly. If I’m placeboing myself, then lalalala I’m not listening.

    • dantheclamman@lemmy.worldOP
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      1 year ago

      omg are you serious? I always felt like sudafed PE didn’t do much but I thought mucinex helped a bunch with sinus congestion. now I’m here not sure if anything is real.

      Edit for those interested: “extended-release guaifenesin was found to have no effect on all 3 patient-related outcome markers analyzed as measured by the Daily Cough and Phlegm Diary, Spontaneous Symptom Severity Assessment score, and the Wisconsin Upper Respiratory Symptom Survey.”

      Edit again with more: “The greatest effects of treatment with guaifenesin/pseudoephedrine were observed for nasal congestion and sinus headache. Time to overall relief was shorter with guaifenesin/pseudoephedrine (P = 0.038). Significantly more patients reported “the medication was helping during the day” on Day 2 with guaifenesin/pseudoephedrine (P = 0.002). Patient assessments of symptom relief showed a significant preference for guaifenesin/pseudoephedrine versus placebo”

    • PetDinosaurs@lemmy.world
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      1 year ago

      I’m with the others. Guaifenisin seems to work pretty well. Even on it’s own. And I’m a major skeptic.

      Not as well as pseudoephedrine or ibuprofen or acetaminophen, but it’s definitely better than dextromethorphan.

      I can’t even pretend to believe that last one does anything. Well, I think idiots use it to get high in a scary way.

    • Blaidd@lemm.ee
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      1 year ago

      Guaifenisin is definitely not a garbage drug, it’s very effective for me in ways that prove it works.

      • Ben Hur Horse Race@lemm.ee
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        1 year ago

        what does it do? I honestly dont know, I havent looked it up.

        just to say, you taking it and believing it has an effect is not proof. large, well regulated, double blind studies are proof.

        if you take it and it does something for you thats good and all you need to know, but it aint proof.

        thats reaaaal similar to people who took Ivermectin when they had covid who recovered from covid and say “thats proof Ivermectin cures covid”

        • Blaidd@lemm.ee
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          1 year ago

          It thins out mucus. The fact that it works very well for me is absolutely proof that it works. I started taking it on recommendation from my doctor. Please explain to me how this is at all analagous to people taking horse ivermectin after doctors denied giving them a prescription?

          Edit to add: guaifenisin is the main ingredient in Mucinex, to those who aren’t familiar

          • servermonky@lemmy.today
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            1 year ago

            I take guaifenisn to combat dry sinuses, and it’s helpful there for me. But I’m not sure I’ve seen a difference in on-label use.

            Unfortunately I deal with frequent nosebleeds and sinus headaches from dryness, and there aren’t a lot of options that work well for me

          • Ben Hur Horse Race@lemm.ee
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            1 year ago

            lots of doctors gave, and are still giving out ivermeticin on prescription. just the ones who ignore the clinical evidence.

            look I’m not saying it doesnt seem to work for you. I’m saying one person taking any med and seeing results is not “proof”, other than for yourself, but thats really all you need to worry about so it doesnt matter.

            • Blaidd@lemm.ee
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              1 year ago

              Guaifenisin aka Mucinex is an FDA approved drug. Maybe you should look it up since you clearly don’t know anything about it? Or just take the word of a stranger on the Internet who says they went to pharmacy school eight years ago

              • Ben Hur Horse Race@lemm.ee
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                1 year ago

                hey, I wasnt taking anyone’s word for anything. I was only saying one person’s experience isn’t proof, and I stand by that.

                I do owe you an apology though, it was late at night and I misunderstood- I confused guaifenisin with phenylephrine, so we were talking about different things which was totally my fault

  • transmatrix@lemmy.world
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    1 year ago

    It’s crazy that enough people think this crap works that it’s a billion dollar industry…

    • RePsyche@lemmy.world
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      1 year ago

      I’m near certain that the companies that sell this useless crap are quite aware of how useless it is.

    • Omega@lemmy.world
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      1 year ago

      Placebo effect is a real thing. Plus, if it just clears up a bit on its own, you might contribute it to the medicine.

    • comador @lemmy.world
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      1 year ago

      Yup, the good stuff is always that 20mg-30mg psedoephedraline they give you the third degree over buying. Worth it.

      • ManosTheHandsOfFate@lemmy.world
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        1 year ago

        I keep both the 4 hour and the 12 hour time-released versions at home. There’s no substitute. I’ll gladly spend a few extra minutes at the pharmacy counter to obtain it.

        • comador @lemmy.world
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          1 year ago

          not a huge fan of the 12 hour ones, but take them myself at times. Still, it just seems, at least to me that the 4 hour doses just work better.

    • coheedcollapse@lemmy.world
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      1 year ago

      Maybe I’m a lightweight, but pseudoephedrine makes me feel weird. I can’t put my finger on it, but maybe a bit jittery and kind of cold. Also hyper - like I’ll want to do chores when I take it

      Works better than anything else for my colds, but it also makes me feel odd so I avoid it unless I’m feeling super trash.

      • Bluescluestoothpaste@sh.itjust.works
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        1 year ago

        It’s basically watered down meth. It’s no joke! That said, it doesn’t make me feel bad at all but everyone’s different and it is a powerful drug.

  • surfrock66@lemmy.world
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    1 year ago

    You know what’s weird? I get severe sinus headaches and regular pseudoenepherine sudafed doesn’t help at all, but these phelylephrine ones do. I’ll even tell my wife “the little reds, not the whites”. Weird.

    • roguetrick@kbin.social
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      1 year ago

      Have you tried a migraine formulation for that? It sounds like you’re actually benefiting from the systemic effects (vasoconstriction) instead of the reduced mucous production. A formulation would include caffeine that also has vasoconstriction in case this is removed from the market.

      • surfrock66@lemmy.world
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        1 year ago

        Weird, here in my area of California the OTC ones are the reds, you have to go to the pharmacist for the white ones.

        • Mouselemming@sh.itjust.works
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          1 year ago

          In my area both are red unless you get the 12-hour controlled-release caplets, those are white. It’s probably just different factories.

    • AnonTwo@kbin.social
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      1 year ago

      I forget but wasn’t it also advertised to have a painkilling effect? Maybe the thing it’s doing for you isn’t the decongestant but that?

      • roguetrick@kbin.social
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        1 year ago

        I actually doubt that. Phenylephrine does have systemic effects that might be beneficial for migraines. That’s not what it was decided to not be effective in with the FDA and not what folks generally use it for. Pseudoephedrine isn’t really that effective for migraines itself.

      • MotoAsh@lemmy.world
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        1 year ago

        Nah, the drug is still a bio-active drug. It DOES do things, just doesn’t help most with the prescribed symptoms because its mechanism of effect is different.

    • Chocrates@lemmy.world
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      1 year ago

      In my area the red ones are the pseudophedrine ones. Never seen the white ones, I just go to the counter because I am not making meth.

    • Catoblepas@lemmy.blahaj.zone
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      1 year ago

      When I had COVID and got really severe congestion, it was some of the worst sinus pain I’ve ever had in my life. I was at the point where I was trying to use a baby nasal bulb to relieve some pressure. The phenylephrine helped me a lot more than any other medication I was trying, including nasal sprays. I also take other sinus medications though, so I wonder if it’s a case of a medication not working well unless it’s used in conjunction with other things?

      I guess it’s possible I experienced a placebo effect, but it seems weird it would do it when nothing else was.

  • ryannathans@lemmy.fmhy.net
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    1 year ago

    This is not new news, in original studies it never outperformed placebo and has cardiovascular health risks. It’s simply never worked, it’s not a secret, it’s just preferred by governments that your access to pseudoephedrine is limited so this was rushed onto shelves

  • SeaJ@lemm.ee
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    1 year ago

    I could have guessed that. Pseudophedrine works great. You just have to ask for it behind the counter because of the whole meth thing.

  • alternative_factor@kbin.social
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    1 year ago

    I got two sinus infections back to back this year and got to learn it the hard way. The doctor was like: “No, you gotta get the REAL stuff!”