It’s honestly a really well designed project. The engine and gui can run independently of each other so you can run the engine headless and interface with it via osc. This is what I do and works very well. The midi sync is very good and remains sync for days on end if your jack is stable. I make music with a friend who runs ableton and we both do live looping with a shared clock and never run into problems. Anyway, give it a spin!
If you’re not yet using reaper I highly advise you to try it out. I run it on debian and it works extremely well. For noise reduction you can use reafir which is one of the built in plugins of reaper. Here is a link with basic tutorial on how to do noise reduction with it.
https://www.homebrewaudio.com/9603/reafir-madness-hidden-noise-reduction-tool-in-reaper/