The world's first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030.

The world’s first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030.

The trial, which will take place at Kyoto University Hospital from September to August 2025, will treat 30 males aged 30-64 who are missing at least one molar. The intravenous treatment will be tested for its efficacy on human dentition, after it successfully grew new teeth in ferret and mouse models with no significant side effects.

“We want to do something to help those who are suffering from tooth loss or absence,” said lead researcher Katsu Takahashi, head of dentistry and oral surgery at Kitano Hospital. “While there has been no treatment to date providing a permanent cure, we feel that people’s expectations for tooth growth are high.”

Following this 11-month first stage, the researchers will then trial the drug on patients aged 2-7 who are missing at least four teeth due to congenital tooth deficiency, which is estimated to affect 1% of people. The team is recruiting for this Phase IIa trial now.

  • ripcord@lemmy.world
    1630·
    6 months ago

    God damn - every single post about something good is just filled with sad sacks that have to find something negative to focus on.

    • arf@lemmy.todayEnglish
      221·
      6 months ago

      Healthcare is a huge sore spot in US culture right now. There’s been too much high-level corruption and greed to have faith in any change.

    • callouscomic@lemm.eeEnglish
      162·
      6 months ago

      Nice of you to just disregard the real suffering that a shitty healthcare and insurance system creates.

    • Sam_Bass@lemmy.world
      142·
      6 months ago

      Well unfortunately we are all products of our environments, where every single beneficial discovery inevitably becomes a commercial endeavour and priced out of reach of the societies that could benefit most from them. You are entitled to be the cheerleader for the discoverers to your hearts content, just as we are allowed to see and react to the after effects of it

    • lobotomo@lemmy.world
      101·
      6 months ago

      Do you disagree with what they actually said though?

      Maybe everyone focuses on the negatives because we just did 5 straight years where it seems like if given the choice between two outcomes positive and negative, we’re living in the timeline where the negative thing always happens.

      • ripcord@lemmy.world
        42·
        6 months ago

        My point is that some bizarre monoculture has developed where people seem to be pathologically unable to accept that something good happened for a change, and to focus on the good thing. Virtually every comment finds some way to find some ultra-pessimistic take. The very best possible take is nearly always something like “wtf took them so long” or “OK, now do X”.

        It should be okay - occasionally - to be happy that something good happened. We have the 98% of other posts out there to moan about and focus on the negative stuff.

        It was bad on Reddit, but it seems even worse here.

        It’s exhausting.

        • lobotomo@lemmy.world
          3·
          6 months ago

          You make a valid point and I wish you’d stop being downvoted for it.

          For those that might be downvoting their comment, just a reminder: downvotes are supposed to reflect the quality of a comment not your disagreement. A bad comment for example is something like “lol get rekt”

          That being said…

          I’m genuinely curious if there’s a place online where you find the discourse to be in anyway slanted toward the optimistic? I’d love to hang out there and after the Reddit exodus, for a while I personally genuinely tried to only have positive discourse here but I think the mood of the zeitgeist is exactly that: when the world seems shitty, everyone’s opinions seem shitty.

    • danc4498@lemmy.worldEnglish
      101·
      6 months ago

      You should expect every post to have a variety of opinions. Some positive, some negative. Not everybody is going to react to posts the same way you do.

      • ripcord@lemmy.world
        33·
        6 months ago

        The vast majority of replies in this thread, and to nearly every positive post - are sadsackery.

        Differing opinions is fine. Raw, pointless pessimism as a monoculture is…not what you’re describing.

        • danc4498@lemmy.worldEnglish
          61·
          6 months ago

          Vast majority, eh? How do you define vast majority? The vast majority of comments in this thread are positive. You’ve decided to focus on the negative comment.

          Raw pointless pessimism? Way to totally ignore the VALID point I brought up in my comment. Insurance (including dental insurance), is bananas in America.